Cloned (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Crystallization (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
C156L | loss of prostaglandin D synthase activity, retention of glutathione S-transferase activity | Rattus norvegicus |
C156Y | loss of prostaglandin D synthase activity, retention of glutathione S-transferase activity | Rattus norvegicus |
K112E | retention of prostaglandin D synthase and glutathione S-transferase activity | Rattus norvegicus |
K198E | retention of prostaglandin D synthase and glutathione S-transferase activity | Rattus norvegicus |
L199F | retention of prostaglandin D synthase and glutathione S-transferase activity | Rattus norvegicus |
R14E | complete loss of prostaglandin D synthase activity and glutathione S-transferase activity | Rattus norvegicus |
R14K | complete loss of prostaglandin D synthase activity and glutathione S-transferase activity | Rattus norvegicus |
W104I | complete loss of prostaglandin D synthase activity and glutathione S-transferase activity | Rattus norvegicus |
Y152F | retention of prostaglandin D synthase and glutathione S-transferase activity | Rattus norvegicus |
Y8F | complete loss of prostaglandin D synthase activity and glutathione S-transferase activity | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
glutathione | - |
Rattus norvegicus | |
0.5 | - |
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate | - |
Rattus norvegicus | |
0.5 | - |
glutathione | conjugation of glutathione to 1-chloro-2,4-dinitrobenzene | Rattus norvegicus | |
3 | - |
1-chloro-2,4-dinitrobenzene | conjugation of glutathione to 1-chloro-2,4-dinitrobenzene | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate + 2 GSH | Rattus norvegicus | - |
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + GSSG + 2 H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | O35543 | - |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
30 | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate | - |
Rattus norvegicus | (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate | - |
? | |
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate + 2 GSH | - |
Rattus norvegicus | (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + GSSG + 2 H+ | - |
? | |
glutathione + 1-chloro-2,4-dinitrobenzene | - |
Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Hematopoietic prostaglandin D synthase | i.e. PGDS | Rattus norvegicus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2 | - |
glutathione | conjugation of glutathione to 1-chloro-2,4-dinitrobenzene | Rattus norvegicus | |
5 | - |
1-chloro-2,4-dinitrobenzene | conjugation of glutathione to 1-chloro-2,4-dinitrobenzene | Rattus norvegicus | |
15 | - |
glutathione | - |
Rattus norvegicus | |
21.7 | - |
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
glutathione | - |
Rattus norvegicus |